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SMB01382

Sigma-Aldrich

2-Methoxyestrone

≥95% (HPLC), from synthetic, solid

Synonym(s):

2,3-Dihydroxy-1,3,5(10)-estratrien-17-one 2-methyl ether, 2-Hydroxyestrone 2-methyl ether, 3-Hydroxy-2-methoxy-1,3,5(10)-estratrien-17-one

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About This Item

Empirical Formula (Hill Notation):
C19H24O3
CAS Number:
362-08-3
Molecular Weight:
300.39
MDL number:
MFCD00056413
UNSPSC Code:
12352211
NACRES:
NA.79

biological source

synthetic

Quality Level

200

Assay

≥95% (HPLC)

form

solid

mp

187-190 °C

storage temp.

2-8°C

SMILES string

C[C@@]12[C@](CCC2=O)([H])[C@]3([H])CCC4=CC(O)=C(OC)C=C4[C@@]3([H])CC1

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General description

2-Methoxyestrone is an endogenous, naturally occurring methoxylated catechol estrogen and an estrone metabolite formed by catechol O-methyltransferase via the intermediate 2-hydroxyestrone. Unlike estrone but similarly to 2-hydroxyestrone and 2-methoxyestradiol, 2-methoxyestrone has very low affinity for the estrogen receptor and lacks significant estrogenic activity

Storage and Stability

Heat sensitive

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Warning

Hazard Statements

H351,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000317466
0000317466
0000224632
0000237987
0000237988

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Urinary estrogen metabolites and gastric cancer risk among postmenopausal women.
Camargo MC, et al.
Cancer reports (Hoboken, N.J.), 5, e1574-e1574 (2022)
Individual and cyclic estrogenic profile in women: Structure and variability of the data.
Bozzolino C, et al.
Steroids, 150, 108432-108432 (2019)
Reproducibility of fifteen urinary estrogens and estrogen metabolites over a 2- to 3-year period in premenopausal women.
Eliassen AH, et al.
Cancer Epidemiology, Biomarkers & Prevention, 18, 2860-2868 (2009)

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