MD0SP07FS1

Millistak+^® HC Pro Pod Depth Filter

D0SP, filtration area 0.77 m², hydrophilic

• Synonym(s): Millistak+ HC Pro Pod Depth Filter, D0SP media series, 0.77 m ² surface area
• UNSPSC Code: 23151806
• eCl@ss: 32031690

Properties

• material: acrylic ; polypropylene ; silica filter aid
• Quality Level: 400
• description: Primary clarification directly out of the bioreactor
• product line: EMPROVE^® Filter
• feature: hydrophilic
• manufacturer/tradename: Millistak+^®
• parameter: 30 psid max. differential pressure (2.1 bar) at 25 °C (Reverse); 30 psid max. differential pressure (2.1 bar) at 80 °C (Forward); 50 psid max. inlet pressure (3.5 bar) at 80 °C
• H: 12.5 in. (32 cm) ; 317 mm
• L: 24.2 in. (62 cm)
• depth: 6.4 in. (16.3 cm)
• filtration area: 0.77 m²
• impurities: <0.25 EU/mL bacterial endotoxins (LAL test, Aqueous extraction)
• input: sample type liquid
• conductivity: 18.9-41.5 μS/cm at 25 °C (product water)
• filter grade: D0SP

Description

General description

The Millistak+^® HC Pro Pod Depth Filter (high capacity synthetic media) is a synthetic depth filter providing a cleaner and more consistent depth filtration media over current diatomaceous earth (DE) and cellulose (CE) based filter offerings. This unit, featured in a Process Scale Pod format with a D0SP media grade, supports primary and secondary clarification as well as downstream filtration applications.

Application

Primary clarification directly out of the bioreactor

Features and Benefits

Synthetic materials of construction

• Reduce TOC extractables and pre-use flush volume requirements by 50%
• No beta glucans to interfere with limulous amoebocyte lysate (LAL) testing for bacterial endotoxins

Lot to lot consistency for successful development and implementation of robust clarification processes

Depth filter media formulation & design

• Provide as much as two times the filtration capacity with equivalent filter retention properties over commercial DE-based benchmarks
• Improved HCP impurity clearance

Disposable Pod device

• Flexible, modular format offers scalability from 5 to 12,000 liters or more
• Robust device format; easy to use and set up

Specifications

Filter Grade: D0SP

Trace metals were measured post pure water flush of 50 L/m² of surface area and 24-hour static soak in pure water. Values based on average of metals extractibles data from three separate uPod device lots. The analysis was made by ICP-MS. The devices were not autoclaved.

Preparation Note

Sterilization Method
Integrity is maintained after 1 autoclave cycle of 60 min @ 123 ºC. Filtration performance may be impacted post autoclave. Recommended for post use decontamination only.

Analysis Note

Product Water Conductivity at 25°C: after a pure water flush 50 L/m² (5 liter per ft²) of media surface area (300 LMH, 10 min). At the end of the flush, a sample was pulled for conductivity measurement. Devices were not autoclaved.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

MILLISTAK+ is a registered trademark of Merck KGaA, Darmstadt, Germany