Interleukin-1 receptor accessory protein (IL-1RAcP), also known as Interleukin-1 receptor 3 (IL-1R-3, IL-1R3) forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kB inducing kinae (NIK) and of NF-kB, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
Specificity
This antibody recognizes the C-terminus of IL-1RAcP.
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human IL-1RAcP.
Application
Detect Interleukin Receptor using this rabbit polyclonal antibody, Anti-IL-1RAcP Antibody validated for use in western blotting & ICC.
Immunocytochemistry Analysis: 5 ug/mL from a representative lot detected IL-1RAcP in HeLa cells.
Research Category Cell Structure
Research Sub Category Cytokines & Cytokine Receptors
Quality
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected IL-1RAcP in 15 µg of HeLa cell lysate.
Target description
~66 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control HeLa cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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The EMBO journal, 39(11), e104150-e104150 (2020-04-30)
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