8.17006

Polyethylene glycol

4000, powder, EMPROVE^® EXPERT, Ph. Eur., NF

• Synonym(s): Poly(ethylene glycol), Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 4000, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 13111021
• EC Index Number: 500-038-2

Properties

• Agency: NF; Ph. Eur.
• Quality Level: 500
• vapor pressure: <0.01 hPa ( 20 °C)
• product line: EMPROVE^® EXPERT
• form: powder; solid
• autoignition temp.: >320 °C (DIN 51794)
• mol wt: average M_n 4000
• technique(s): API processing | nano-milling: suitable
• pH: 5-7 (20 °C, 100 g/L in H₂O)
• mp: 53-58 °C
• transition temp: flash point 270 °C
• density: 1.2 g/cm³ at 20 °C
• application(s): liquid formulation; pharma/biopharma processes; pharmaceutical; semi-solid formulation; solid formulation; solubility enhancement
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

When working on a pharmaceutical formulation, there are specific considerations to make and challenging hurdles to take before you can successfully launch your final drug product - formulation stability, release kinetics and bioavailability limitations just to name a few. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Polyethylene glycol (PEG) is a multipurpose polymer which can be applied in solid, semi-solid and liquid formulations. Its broad functional spectrum includes e.g. improvement of API solubility, acting as a lubricant for tablet coating, function as a carrier, and many more. Our comprehensive portfolio of PEGs comprises diverse polymer sizes of different molecular weights to meet your specific application and needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 281.5 °F - closed cup
• Flash Point(C): 138.6 °C - closed cup