688100

YC-1

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase.

• Synonym(s): YC-1, 3-(5ʹ-Hydroxymethyl-2ʹ-furyl)-1-benzylindazole
• Empirical Formula (Hill Notation): C₁₉H₁₆N₂O₂
• CAS Number: 170632-47-0
• Molecular Weight: 304.34
• MDL number: MFCD06407798
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• color: off-white to pale yellow
• solubility: DMSO: 10 mg/mL; methanol: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• InChI key: OQQVFCKUDYMWGV-UHFFFAOYSA-N

Description

General description

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent.

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activator of soluble guanylyl cyclase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yeo, E.J., et al. 2003. J. Natl Cancer Inst.95, 516.
Mulsch, A., et al. 1997. Br. J. Pharmacol. 120, 681.
Teng, C.M., et al. 1997. Eur. J. Pharmacol. 320, 161.
Wu, C.C., et al. 1997. Biochem. Biophys. Res. Commun. 231, 412.
Wu, C.C., et al. 1995. Br. J. Pharmacol. 116, 1973.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable