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Trolox

A cell-permeable, water-soluble derivative of vitamin E with antioxidant properties. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.

Synonym(s):

Trolox, 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid

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About This Item

Empirical Formula (Hill Notation):
C14H18O4
CAS Number:
53188-07-1
Molecular Weight:
250.29
MDL number:
MFCD00006846
UNSPSC Code:
12352205

Assay

≥98% (titration)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white
 white to pale green
 white to pale yellow

solubility

water: 0.5 mg/mL (slightly soluble)
ethanol: 150 mg/mL
methanol: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)

InChI key

GLEVLJDDWXEYCO-UHFFFAOYSA-N

General description

A cell-permeable, water-soluble derivative of vitamin E with antioxidant properties. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.
A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.

Application


  • Structural characterization of peroxyl radical oxidative products of antioxidant peptides from hydrolyzed proteins.: This study highlights the application of Trolox in understanding the oxidative modifications of antioxidant peptides, which could help in the development of more effective antioxidative therapies and supplements (Esfandi et al., 2024).

  • Extraction of bioactive compounds from pecan nutshell: An added-value and low-cost alternative for an industrial waste.: Trolox is utilized to evaluate the antioxidant capacity of bioactive extracts from pecan shells, presenting a sustainable approach to utilizing agricultural waste (Cardona Jimenez et al., 2024).

  • Investigation into the role of carboxylic acid and phenolic hydroxyl groups in the plant biostimulant activity of a humic acid purified from an oxidized sub-bituminous coal.: Utilizing Trolox equivalent antioxidant capacity (TEAC) assay, this research explores the bio-stimulatory properties of humic substances, enhancing our understanding of their role in agriculture (Lamar et al., 2024).

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Other Notes

Salgo, M.G. and Pryor, W.A. 1996. Arch. Biochem. Biophys. 333, 482.
McClain, D.E., et al. 1995. FASEB J. 9, 1345.
Salgo, M.G., et al. 1995. Arch. Biochem. Biophys.322, 500.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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