437628

Lipopolysaccharide

from Salmonella minnesota, , lyophilized, TLR4 signaling stimulator, Calbiochem

• UNSPSC Code: 12352201
• NACRES: NA.77

Properties

• product name: Lipopolysaccharide, Ultra Pure, Salmonella minnesota R595 (Re), Phenol-petroleum ether extracted lipopolysaccharide (LPS) containing ≤0.3% proteins.
• Quality Level: 100
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: 0.5% triethylamine: 1 mg/mL; water: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

Phenol-petroleum ether extracted lipopolysaccharide (LPS) containing ≤0.3% proteins. LPS 595 (Re) has been shown to stimulate Toll-like receptor-4 (TLR4), but not TLR2, signaling in human cell lines.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Stimulate Toll-like receptor-4 (TLR4) signaling in human cell lines

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Preparation Note

Warming to 37°C with intermittent vortexing or sonication may be required to achieve complete solubilization in H₂O.

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months.

Other Notes

Hirschfeld, M., et al. 2000. J. Immunol.165, 618.
Tapping, R.I., et al. 2000. J. Immunol.165, 5780.
Galanos, C., et al. 1969. Eur. J. Biochem.9, 245.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable