178496

Apoptosis Activator VI, CD437/AHPN

The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Apoptosis Activator VI, CD437/AHPN, 6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid
• Empirical Formula (Hill Notation): C₂₇H₂₆O₃
• CAS Number: 125316-60-1
• Molecular Weight: 398.49
• MDL number: MFCD03106506
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 39 mg/mL; ethanol: 39 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
• InChI key: LDGIHZJOIQSHPB-UHFFFAOYSA-N

Description

General description

A cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer.

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 months at -20°C.

Other Notes

Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm.366, 840.
Holmes, W.F., et al. 2004. J. Cell. Physiol.199, 317.
Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci.10, 44.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable