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924172

Sigma-Aldrich

Tris[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]silane

Synonym(s):

HSi(OCH(CF3)2)3

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About This Item

Empirical Formula (Hill Notation):
C9H4F18O3Si
CAS Number:
2473688-54-7
Molecular Weight:
530.18
UNSPSC Code:
12352101
NACRES:
NA.22

form

liquid

Quality Level

100

refractive index

n/D 1.284

density

1.609 g/mL

Application

Tris[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]silane is a silylating reagent used to silylate the C-terminus of unprotected amino acids and peptides, allowing for coupling with N-silylated amino acids and peptides to form discrete peptide bonds using a one-pot method.

Other Notes

Peptide Bond Formation of Amino Acids by Transient Masking with Silylating Reagents

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Wataru Muramatsu et al.
Journal of the American Chemical Society, 143(18), 6792-6797 (2021-05-01)
A one-pot peptide bond-forming reaction has been developed using unprotected amino acids and peptides. Two different silylating reagents, HSi[OCH(CF3)2]3 and MTBSTFA, are instrumental for the successful implementation of this approach, being used for the activation and transient masking of unprotected

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