655414

2-(2′-Di-tert-butylphosphine)biphenylpalladium(II) acetate

97%

• Synonym(s): Palladium, (acetato-ΚO) [2′-[bis (1,1 dimethylethyl) phosphino-ΚP] [1,1′-biphenyl]-2-yl ΚC]
• Empirical Formula (Hill Notation): C₂₂H₂₉O₂PPd
• CAS Number: 577971-19-8
• Molecular Weight: 462.86
• MDL number: MFCD04117716
• UNSPSC Code: 12352300
• PubChem Substance ID: 24884102
• NACRES: NA.22

Properties

• Assay: 97%
• form: solid
• reaction suitability: core: palladium; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Cross Couplings; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: catalyst
• mp: 130-140 °C (dec.) (lit.)
• SMILES string: CC(=O)[Pd]1c2ccccc2-c3ccccc3[PH]1(C(C)(C)C)C(C)(C)C
• InChI: 1S/C20H26P.C2H4O2.Pd/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16;1-2(3)4;/h7-12,14-15H,1-6H3;1H3,(H,3,4);/q;;+1/p-1
• InChI key: IEYDYAASBZOBOC-UHFFFAOYSA-M

Description

General description

2-(2′-Di-tert-butylphosphine)biphenylpalladium(II) acetate is a novel, air- and moisture-and thermally stable catalyst.

Application

It can be used as a pre-catalyst for the amination of aryl chlorides. It can also be used to prepare N-methyl-6-heterocyclic-1-oxoisoindoline derivatives via Buchwald-Hartwig amination reaction of N-methyl-6- bromoisoindoline-1-one with different amines under microwave condition.

Precatalyst for Buchwald-Hartwig amination reaction.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves