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29295

Sigma-Aldrich

3-Cyclohexyl-D-alanine hydrate

≥99.0% (calc. based on dry substance, NT), ~1 mol/mol water

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About This Item

Empirical Formula (Hill Notation):
C9H17NO2 · xH2O
CAS Number:
58717-02-5
Molecular Weight:
171.24 (anhydrous basis)
Beilstein:
3197315
MDL number:
MFCD00217056
UNSPSC Code:
12352200
PubChem Substance ID:
57648357
NACRES:
NA.22

Assay

≥99.0% (calc. based on dry substance, NT)

form

solid

optical activity

[α]20/D −12±1°, c = 1% in 1 M HCl (dry matter)

impurities

~1 mol/mol water

application(s)

peptide synthesis

SMILES string

O.N[C@H](CC1CCCCC1)C(O)=O

InChI

1S/C9H17NO2.H2O/c10-8(9(11)12)6-7-4-2-1-3-5-7;/h7-8H,1-6,10H2,(H,11,12);1H2/t8-;/m1./s1

InChI key

HDJQIWAIDCEDEF-DDWIOCJRSA-N

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers.
Christian A Olsen et al.
ChemMedChem, 1(3), 303-305 (2006-08-08)
Takao Nomura et al.
Biopolymers, 95(6), 410-419 (2011-02-01)
Stabilization of protein structures and protein-protein interactions are critical in the engineering of industrially useful enzymes and in the design of pharmaceutically valuable ligands. Hydrophobic interactions involving phenylalanine residues play crucial roles in protein stability and protein-protein/peptide interactions. To establish
Chad D Tatko et al.
Journal of the American Chemical Society, 126(7), 2028-2034 (2004-02-20)
We have examined the impact of C-H...pi and hydrophobic interactions in the diagonal position of a beta-hairpin peptide through comparison of the interaction of Phe, Trp, or Cha (cyclohexylalanine) with Lys or Nle (norleucine). NMR studies, including NOESY and chemical
Nathan A Schnarr et al.
Journal of the American Chemical Society, 124(33), 9779-9783 (2002-08-15)
Specific coiled-coil heterotrimers result from steric matching of hydrophobic core side chains. A 2:1 heterotrimer is formed by peptides containing alanine or cyclohexylalanine, respectively, at a central core residue. Detailed thermodynamic analysis reveals that the designed complex is considerably more
Christopher J Pace et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(19), 5832-5836 (2012-04-05)
CH-π stacks up! Using the protein α(2) D as a model system, we estimate that a CH-π contact between cyclohexylalanine (Cha) and phenylalanine (F) contributes approximately -0.7 kcal  mol(-1) to the protein stability. The stacking F-Cha pairs are sequestered in the
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