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Sigma-Aldrich

L-Glutamic acid

99%

Synonym(s):

(S)-2-Aminopentanedioic acid, Glu

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About This Item

Linear Formula:
HO2CCH2CH2CH(NH2)CO2H
CAS Number:
56-86-0
Molecular Weight:
147.13
Beilstein:
1723801
EC Number:
200-293-7
MDL number:
MFCD00002634
UNSPSC Code:
12352209

Assay

99%

optical activity

[α]20/D +31.5°, c = 2 in 5 M HCl

mp

205 °C (dec.) (lit.)

solubility

H2O: soluble 140 gm/l at 100 degrees c
H2O: soluble 21.86 gm/l at 50 degrees c
H2O: soluble 55.32 gm/l at 75 degrees c
H2O: soluble 8.64 gm/l at 25 degrees c
hydrochloric acid: soluble 10% in 1 N, clear, colorless

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

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Application

L-Glutamic acid has been used as a supplement for selection medium, SORB-TOP-His.

Biochem/physiol Actions

L-Glutamic acid along with l-Lysine is used for preparation of Bifunctional DTPA-like Ligands. L-glutamic acid can stimulate the spontaneous release of [3H] dopamine ( [3H] DA).
An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

replaced by

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices.
M F Giorguieff et al.
Neuroscience letters, 6(1), 73-77 (1977-10-01)
Luigi F Agnati et al.
Pharmacological reviews, 55(3), 509-550 (2003-07-19)
The molecular basis for the known intramembrane receptor/receptor interactions among G protein-coupled receptors was postulated to be heteromerization based on receptor subtype-specific interactions between different types of receptor homomers. The discovery of GABAB heterodimers started this field rapidly followed by
Ulrike Pannasch et al.
Nature neuroscience, 17(4), 549-558 (2014-03-04)
Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellular and molecular mechanisms
Kimberly J Dougherty et al.
Neuron, 80(4), 920-933 (2013-11-26)
Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilaterally
Nils Muhlert et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 833-839 (2014-01-17)
Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test
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