The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development of therapeutic intervention strategies. While there has been significant progress in defining the pathophysiology of alphaviral disease, relatively little is known
Xenobiotica; the fate of foreign compounds in biological systems, 32(5), 349-362 (2002-06-18)
1. Organ-specific biotransformation was studied in human and rat liver, lung, kidney and small intestine slices and compared on a protein basis, using four model substances. 2. Deethylation of lidocaine was highest in liver slices from both man and rat
The American journal of clinical nutrition, 82(3), 559-567 (2005-09-13)
Resistant starch may modulate insulin sensitivity, although the precise mechanism of this action is unknown. We studied the effects of resistant starch on insulin sensitivity and tissue metabolism. We used a 4-wk supplementation period with 30 g resistant starch/d, compared
Journal of inorganic biochemistry, 75(1), 55-61 (1999-07-14)
Various divalent rhodium complexes Rh2(L)4 (L = acetate, propionate, butyrate, trifluoroacetate and trifluoroacetamidate) have been found to bind to non-defatted human serum albumin (HSA) at molar ratios about 8:1. The circular dichroism measurements showed that the more liposoluble carboxylates, butyrate
Biochimica et biophysica acta, 1801(11), 1175-1183 (2010-08-10)
Undigested food is fermented in the colon by the microbiota and gives rise to various microbial metabolites. Short-chain fatty acids (SCFA), including acetic, propionic and butyric acid, are the principal metabolites produced. However, most of the literature focuses on butyrate
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