UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast)
Synonyms:
HUPF3A, RENT3A, UPF3
Species:
Human UPF3A (65110), Mouse Upf3a (67031), Rat Upf3a (361176), chicken UPF3A (418734), cow UPF3A (529442), domestic cat UPF3A (101099267), dog UPF3A (607836), domestic guinea pig Upf3a (100724694), Zebrafish upf3a (566608), naked mole-rat Upf3a (101724600)
UniProtKB ID:
Gene ID:
- Human(65110) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(67031) UPF3 regulator of nonsense transcripts homolog A (yeast)
- Rat(361176) UPF3 regulator of nonsense transcripts homolog A (yeast)
- chicken(418734) UPF3 regulator of nonsense transcripts homolog A (yeast)
- cow(529442) UPF3 regulator of nonsense transcripts homolog A (yeast)
- domestic cat(101099267) UPF3 regulator of nonsense transcripts homolog A (yeast)
- dog(607836) UPF3 regulator of nonsense transcripts homolog A (yeast)
- domestic guinea pig(100724694) UPF3 regulator of nonsense transcripts homolog A (yeast)
- Zebrafish(566608) UPF3 regulator of nonsense transcripts homolog A (yeast)
- naked mole-rat(101724600) UPF3 regulator of nonsense transcripts homolog A (yeast)
- sheep(101121945) UPF3 regulator of nonsense transcripts homolog A (yeast)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-UPF3A antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-UPF3A antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot