PTPRF
protein tyrosine phosphatase, receptor type, F
Synonyms:
LAR
Species:
Human PTPRF (5792), Mouse Ptprf (19268), Rat Ptprf (360406), chicken PTPRF (424568), Zebrafish ptprf (140819), domestic cat PTPRF (101081238), Horse PTPRF (100053205), dog PTPRF (475389), sheep PTPRF (101111588), cow PTPRF (512072) ...More
UniProtKB ID:
Gene ID:
- Human(5792) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
- Mouse(19268) protein tyrosine phosphatase, receptor type, F
- Rat(360406) protein tyrosine phosphatase, receptor type, F
- chicken(424568) protein tyrosine phosphatase, receptor type, F
- Zebrafish(140819) protein tyrosine phosphatase, receptor type, F
- domestic cat(101081238) protein tyrosine phosphatase, receptor type, F
- Horse(100053205) protein tyrosine phosphatase, receptor type, F
- dog(475389) protein tyrosine phosphatase, receptor type, F
- sheep(101111588) protein tyrosine phosphatase, receptor type, F
- cow(512072) protein tyrosine phosphatase, receptor type, F
- naked mole-rat(101711685) protein tyrosine phosphatase, receptor type, F
- domestic guinea pig(100720106) protein tyrosine phosphatase, receptor type, F
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PTPRF antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-PTPRF (C-terminal) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
PTPRF (1275-1897), active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human