From the stained slide, it's only possible to determine if the tissue contains amyloid or not. the type of amyloid provided was never subclassified.
TTR002
Amyloid TISSUE-TROL™ Control Slides
from human heart
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About This Item
UNSPSC Code:
41116121
NACRES:
NA.47
Pricing and availability is not currently available.
Recommended Products
biological source
human heart
application(s)
hematology
histology
storage temp.
room temp
General description
Amyloid TISSUE-TROL™ Control Slides are histology slides embedded with human heart tissue. The embedded heart tissue is embedded in paraffin and contains Amyloid proteins. The product comes with one reference slide stained using Congo Red (amyloid stain). Historically, amyloids have been described as fibrillar protein deposits often associated with a disease. Disease caused by amyloids are referred to as “amyloidosis”.
Application
Amyloid TISSUE-TROL™ Control Slides is used as a positive control to study pancreatic inflammation.
Components
Box contains 24 unstained slides plus one reference slide stained using Amyloid Stain, Congo Red (Procedure No. HT60).
Legal Information
TISSUE-TROL is a trademark of Sigma-Aldrich Co. LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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J C Rochet et al.
Current opinion in structural biology, 10(1), 60-68 (2000-02-19)
Recent progress has improved our knowledge of how proteins form amyloid fibrils. Both 'natively unfolded' and globular proteins have been shown to initiate fibrillization by adopting a partially structured conformation. Oligomeric prefibrillar intermediates have been extensively characterized with respect to
Pancreatic inflammation and increased islet macrophages in insulin resistant juvenile primates.
Nicol L, et al.
The Journal of Endocrinology, JOE-J12 (2013)
L E Nicol et al.
The Journal of endocrinology, 217(2), 207-213 (2013-02-20)
Chronic high caloric intake has contributed to the increased prevalence of pediatric obesity and related morbidities. Most overweight or obese children, however, do not present with frank metabolic disease but rather insulin resistance or subclinical precursors. The innate immune system
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what specific Amyloid deposits do these slides consist of? Are they TTR or Light chain/AL?
1 answer-
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please confirm that the Armyloid Tissue Trol slides are in fact formalin fixed or not
1 answer-
All Tissue Trol slides, including the Amyloid Tissue Trol slides, are fixed in 10% Neutral Buffered Formalin and paraffin embedded.
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