This product is lyophilized in PBS. Reconstitute in 100uL of endotoxin-free water. Aliquot to avoid multiple freeze/thaw cycles and store at -20°C for up to 3 months.
SRP8010
GPX1 human
recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
Synonym(s):
Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1
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biological source
human
recombinant
expressed in E. coli
tag
His tagged
Assay
>90% (SDS-PAGE)
form
lyophilized
mol wt
~25 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GPX1(2876)
General description
Biochem/physiol Actions
GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.[1][3]
Physical form
Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Association of polymorphisms of adiponectin gene promoter-11377C/G, glutathione peroxidase-1 gene C594T, and cigarette smoking in nonalcoholic fatty liver disease.
Zhang CX, et al.
Journal of the Chinese Medical Association : JCMA, 79, 195-195 (2016)
Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians.
Donadio JL, et al.
Nutrients, 8, E81-E81 (2016)
Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.
Xiao BH, et al.
BioMed Research International, 2016, 3029810-3029810 (2016)
Manon Ros et al.
Nature cell biology, 22(11), 1371-1381 (2020-10-21)
Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show
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how to aliquots this human Gpx enzyme, and mention the solvent/medium in which GPx enzyme has to be aliquoted for my use?
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