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SML1391

Sigma-Aldrich

Olmesartan medoxomil

≥98% (HPLC)

Synonym(s):

4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, CS-866

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About This Item

Empirical Formula (Hill Notation):
C29H30N6O6
CAS Number:
Molecular Weight:
558.59
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCCC1=NC(C(O)(C)C)=C(C(OCC2=C(C)OC(O2)=O)=O)N1CC(C=C3)=CC=C3C4=CC=CC=C4C5=NN=NN5

InChI

1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)

InChI key

UQGKUQLKSCSZGY-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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Biochem/physiol Actions

Olmesartan medoxomil is a selective Angiotensin II Type I receptor blocker and antihypertensive drug. Olmesartan medoxomil is converted enzymatically to the active form olmesartan.
Olmesartan medoxomil is considered as an antihypertensive agent. It is an angiotensin 2 type 1 antagonist receptor. It is a prodrug which releases the parent compound olmesartan after ingestion. Olmesartan is ejected via kidney and liver. In humans, olmesartan protects renal and cardiovascular systems. This drug may be used in the treatment of hypertension.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Angiotensin II Inhibitors: Advances in Research and Application (2012)
Hans R Brunner
Journal of human hypertension, 16 Suppl 2, S13-S16 (2002-04-23)
The new orally active angiotensin II (A II) type-1 receptor antagonist olmesartan medoxomil is a prodrug, which is rapidly converted in vivo to the active metabolite, olmesartan. The pharmacology, antihypertensive efficacy and safety of olmesartan medoxomil and/or the pharmacologically active
Current Cardiovascular Drugs (2005)
Case Studies in Modern Drug Discovery and Development (2012)
Linear mixed-effects model of QTc prolongation for olmesartan medoxomil.
SaeHeum Song et al.
Journal of clinical pharmacology, 56(1), 96-100 (2015-06-23)

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