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Key Documents

SAB4501941

Sigma-Aldrich

Anti-MYC antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Myc proto-oncogene protein, c-myc

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P01106

UniProt accession no.

P01106

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYC(4609)

General description

The MYC (MYC proto-oncogene, bHLH transcription factor) gene is mapped to human chromosome 8q24.21. This gene encodes an oncogenic transcription factor and belongs to the MYC gene family. Anti-MYC antibody detects endogenous levels of total MYC protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human MYC.

Immunogen Range: 386-435

Application

Anti-MYC antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

MYC proto-oncogene, bHLH transcription factor (MYC) is known to induce tumor growth in a variety of cancer types. c-MYC overexpression promotes DNA replication, transcription, translation and metabolism in cancer cells. Upregulation of this gene is observed in pancreatic ductal adenocarcinoma and diffuse large B-cell lymphoma (DLBCL).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Knockdown of ASF1B inhibits cell proliferation, migration, invasion and cisplatin resistance in gastric cancer through the Myc pathway.
Zhang, et al.
Oncology Letters, 25, 242-242 (2023)
Checkpoint suppressor 1 suppresses transcriptional activity of ERalpha and breast cancer cell proliferation via deacetylase SIRT1
Xu, Z, et al.
Cell Death & Disease, 9(5), 559-559 (2018)
c-MYC amplification and c-myc protein expression in pancreatic acinar cell carcinomas. New insights into the molecular signature of these rare cancers
La RS, et al.
Virchows Archiv, 9(5), 1-7 (2018)
PVT1 dependence in cancer with MYC copy-number increase
Tseng YY, et al.
Nature, 512(7512), 82-82 (2014)
Zhaowei Xu et al.
Cell death & disease, 9(5), 559-559 (2018-05-13)
Breast cancer is a highly heterogeneous carcinoma in women worldwide, but the underlying mechanisms that account for breast cancer initiation and development have not been fully established. Mounting evidence indicates that Checkpoint suppressor 1 (CHES1) is tightly associated with tumorigenesis
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