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Key Documents

M2521

Sigma-Aldrich

IgM, Lambda from murine myeloma

clone MOPC 104E, ascites fluid, lyophilized powder

Synonym(s):

Mouse IgM-λ

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

clone

MOPC 104E, monoclonal

form

lyophilized powder

storage temp.

2-8°C

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General description

The MOPC-104E tumor line that produces mouse IgM is a mineral oil induced plasmacytoma originated and carried intraperitoneally in BALB/c mice. Mouse consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. IgM is present on the surface of B lymphocytes in its monomeric form.

Specificity

Antigen Specificity: α(1→3) glucose

Application

IgM, λ from murine myeloma has been used as control in chromatin immunoprecipitation analysis. It has also been used in immunohistochemitsry.
IgM, λ from murine myeloma was used as a control antibody in ChIP analysis of GATA-1-null and GATA-1-positive G1E cells.

Biochem/physiol Actions

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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GATA-1-mediated Transcriptional Repression Yields Persistent Transcription Factor IIB-Chromatin Complexes
Martowicz ML, et al.
The Journal of biological chemistry, 281(49), 37345-37352 (2006)
D Chen et al.
The American journal of physiology, 277(3), H1100-H1106 (1999-09-14)
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is thought to play an important role in the pathogenesis of atherosclerosis and restenosis. Previous studies have implicated the extracellular matrix protein thrombospondin-1 (TSP1) in mitogen-dependent proliferation of VSMCs. In this study
Molecular Genetics of Immunoglobulin, 17 (1987)
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Zhou S, et al.
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Diabetic nephropathy is characterized by early hypertrophy in both glomerular and tubuloepithelial elements. However, no studies to date have established a direct causal link between hyperglycaemia and renal hypertrophy. Our previous studies have found that high glucose does not induce

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