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biological source
canine bone (normal)
packaging
pkg of 500,000 cells
manufacturer/tradename
Cell Applications, Inc
growth mode
Adherent
karyotype
2n = 78
morphology
osteoblast
technique(s)
cell culture | mammalian: suitable
relevant disease(s)
arthritis; osteoporosis
shipped in
dry ice
storage temp.
−196°C
General description
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Canine osteoblasts provide an excellent model system for studies relevant to the skeletal system, including mechanisms of cancerogenesis.
Canine osteoblasts have been used to define a biomarker profile of canine osteosarcoma (Milovancev, 2013), elucidate the roles of oncogenic STAT3 (Fossey, 2009, 2011) and canonical Wnt signaling (Piskun, 2013) pathways, and to develop personalized osteosarcoma treatments by testing Src inhibitor dasatinib (Davis, 2013), procaspase-3 activating compound PAC-1 (Book, 2012), HSP90 inhibitor STA-1474 (McCleese, 2009) and STAT3 inhibitor LLL12 (Couto, 2012, 2013).
Characterization: Positive for bone mineralization.
Canine osteoblasts provide an excellent model system for studies relevant to the skeletal system, including mechanisms of cancerogenesis.
Canine osteoblasts have been used to define a biomarker profile of canine osteosarcoma (Milovancev, 2013), elucidate the roles of oncogenic STAT3 (Fossey, 2009, 2011) and canonical Wnt signaling (Piskun, 2013) pathways, and to develop personalized osteosarcoma treatments by testing Src inhibitor dasatinib (Davis, 2013), procaspase-3 activating compound PAC-1 (Book, 2012), HSP90 inhibitor STA-1474 (McCleese, 2009) and STAT3 inhibitor LLL12 (Couto, 2012, 2013).
Characterization: Positive for bone mineralization.
Cell Line Origin
Bone
Application
model for skeletal system research, signaling pathways, bone morphogenesis, gene expression, cell activation and proliferation, wound healing, bone formation and regeneration, treatment strategies, tissue engineering, in vitro bone models, mineralization, hormone treatments
Components
Canine Osteoblast Basal Medium containing 10% FBS & 10% DMSO
Preparation Note
- 1st passage, >500,000 cells in Canine Osteoblast Basal Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 10 doublings
Subculture Routine
Please refer to the CnOb Culture Protocol.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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