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338R-2

Sigma-Aldrich

TdT (EP266) Rabbit Monoclonal Primary Antibody

Synonym(s):

Terminal Deoxynucleotidyl Transferase

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP266, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (338R-24)
vial of 0.1 mL concentrate Research Use Only (338R-24-RUO)
vial of 0.5 mL concentrate (338R-25)
vial of 1.0 mL concentrate (338R-26)
vial of 1.0 mL concentrate Research Use Only (338R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (338R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (338R-27)
vial of 7.0 mL pre-dilute ready-to-use (338R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (338R-28-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

isotype

IgG

control

thymus

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... DNTT(1791)

General description

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerase that adds nucleotides randomly to single-stranded DNA. This randomization plays a role in acquired immunity by increasing antigen receptor diversity and aiding in the generation of immunoglobulins and T cell antigen receptors. TdT expression is characteristic of lymphoid progenitor cells in thymus and tonsils. Anti-TdT is a useful marker for lymphoblastic lymphomas and has been observed in some cases of acute myeloid leukemia.

Quality


IVD
IVD
IVD
RUO

Linkage

TdT Positive Control Slides, Product No. 338S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections)

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Edward A Motea et al.
Biochimica et biophysica acta, 1804(5), 1151-1166 (2009-07-15)
Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct each incorporation event. There is, however, one unique DNA polymerase designated terminal
James A Strauchen et al.
International journal of surgical pathology, 11(1), 21-24 (2003-02-25)
To investigate the occurrence of lymphoid progenitor cells in human tonsils, we studied tonsils from children and adults by immunohistochemistry by using a panel of antibodies to antigens associated with lymphoid progenitor cells, including terminal deoxynucleotidyl transferase (TdT), CD10 (CALLA)
J Suzumiya et al.
The Journal of pathology, 182(1), 86-91 (1997-05-01)
Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase located in the cell nucleus which catalyses the polymerization of deoxynucleotides at the 3'hydroxyl ends of oligo- or polydeoxynucleotide initiators without a template. TdT is known as a useful marker for the
D A Arber et al.
American journal of clinical pathology, 106(4), 462-468 (1996-10-01)
The immunohistochemical evaluation of acute leukemia specimens has been limited in the past due of the inability to detect many lineage-related antigens in paraffin sections. With the improvement in immunohistochemical methods as well as the introduction of new antibodies, these

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