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Key Documents

Y0000734

Dacarbazine impurity A

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

3,7-Dihydro-4H-imidazo[4,5-d]-1,2,3-triazin-4-one, 2-Azahypoxanthine, NSC 22419

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About This Item

Empirical Formula (Hill Notation):
C4H3N5O
CAS Number:
Molecular Weight:
137.10
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

dacarbazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C4H3N5O/c10-4-2-3(6-1-5-2)7-9-8-4/h1,9H,(H,8,10)

InChI key

WXKVKFJUCMCVFI-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dacarbazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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P P Saunders et al.
Chemico-biological interactions, 58(3), 319-331 (1986-06-01)
Decomposition of the antitumor agent 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC, Dacarbazine) produces several potentially toxic compounds, the concentration of which depend on incubation parameters such as pH, temperature and illumination. The action of DTIC on chinese hamster ovary (CHO) cell clone formation in
D Fiore et al.
Antimicrobial agents and chemotherapy, 27(6), 977-979 (1985-06-01)
A high-pressure liquid chromatographic method has been developed that allows for the simultaneous analysis of dacarbazine (DTIC), 5-aminoimidazole-4-carboxamide (AIC), and 2-azahypoxanthine (2-AZA) in plasma or urine. Plasma samples were prepared by ultrafiltration, whereas urine samples were filtered and diluted for
Disclosure of the "fairy" of fairy-ring-forming fungus Lepista sordida.
Jae-Hoon Choi et al.
Chembiochem : a European journal of chemical biology, 11(10), 1373-1377 (2010-05-21)
B Hernández et al.
Journal of computer-aided molecular design, 11(2), 153-162 (1997-03-01)
The tautomerism of 2-azaadenine and 2-hypoxanthine has been examined in the gas phase and in aqueous solution. The tautomerism in the gas phase has been studied by means of semiempirical and ab initio quantum-mechanical computations, as well as density-functional calculations.
L L Bennett et al.
Biochemical pharmacology, 34(8), 1293-1304 (1985-04-15)
The metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine were studied to elucidate the biochemical basis for their known cytotoxicities. 2-Azaadenosine is a known substrate for adenosine kinase. That 2-azahypoxanthine is a substrate for hypoxanthine (guanine) phosphoribosyltransferase is shown by

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