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H4125

Supelco

Hesperetin

analytical standard

Synonym(s):

3′,5,7-Trihydroxy-4′-methoxyflavanone, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone

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About This Item

Empirical Formula (Hill Notation):
C16H14O6
CAS Number:
69097-99-0
Molecular Weight:
302.28
MDL number:
MFCD00016956
UNSPSC Code:
41116107
PubChem Substance ID:
329815205
NACRES:
NA.24

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1ccc(cc1O)C2CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3

InChI key

AIONOLUJZLIMTK-UHFFFAOYSA-N

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General description

Hesperetin is an aglycon form of flavonoid, which can be found in peels of citrus fruits.

Application

Hesperetin has been used as a standard in studies involving the cytotoxic effect of hesperetin on doxorubicin-resistant MCF-7 cells using enzyme-linked immunosorbent assay (ELISA) technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Dietary flavanone with chemopreventive effect.

Other Notes

For this product we use the non-stereospecific CAS number. It is expected that the natural enantiomer is predominant, however the substance is prone to racemization in solution. The product is therefore not specified stereospecifically and is only recommended to be used for non-stereospecific analysis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6619
BCCJ6179
BCCK1228
BCCK3892
BCCF5489

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Increasing sensitivity of MCF-7/DOX cells towards doxorubicin by hesperetin through suppression of P-glycoprotein expression
Sarmoko, et al.
Indonesian Journal of Pharmacy, 25, 84-84 (2014)
Manoj Aswar et al.
Pharmacology, biochemistry, and behavior, 124, 101-107 (2014-05-30)
Behavioral, biochemical and gene expression changes were investigated in a rat model of partial sciatic nerve ligation (PSNL) after administration of hesperetin (20, 50mg/kg; p.o.), pregabalin (10mg/kg; p.o.) or vehicle (1 ml/kg, p.o.). Thirty-six animals were randomly divided into six
Benjamin Dilberger et al.
Nutrients, 11(8) (2019-08-16)
(1) Background: Polyphenols (PP) play an important role in the prevention of non-communicable diseases and may contribute to healthy aging. To investigate the molecular and cellular aspects of PP metabolites on longevity with a focus on mitochondrial function, we applied
Fei Ding et al.
Molecular bioSystems, 11(4), 1119-1133 (2015-02-13)
Naturally multifunctional Rutaceae hesperidin and its aglycone hesperetin have a great variety of biopharmaceutical activities, e.g. anti-cancer, anti-inflammatory, antioxidant and antitumor; however, the influence of the molecular structures of hesperidin and hesperetin, and in particular, the structural properties such as
Mari Nekohashi et al.
PloS one, 9(5), e97901-e97901 (2014-05-27)
Niemann-Pick C1-Like 1 (NPC1L1) mediates cholesterol absorption, and ezetimibe is a potent NPC1L1 inhibitor applicable for medication of hypercholesterolemia. Epidemiological studies demonstrated that consumption of polyphenols correlates with a decreased risk for atherosclerosis due to their antioxidant effect. This activity
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