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Supelco

1-Methoxy-2-propanol

analytical standard

Synonym(s):

Propylene glycol methyl ether, Propyleneglycol monomethyl ether

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About This Item

Linear Formula:
CH3CH(OH)CH2OCH3
CAS Number:
Molecular Weight:
90.12
Beilstein:
1731270
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

vapor density

3.12 (vs air)

vapor pressure

10.9 mmHg ( 25 °C)

Assay

≥99.7% (GC)

autoignition temp.

532 °F

shelf life

limited shelf life, expiry date on the label

expl. lim.

13.8 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.403 (lit.)
n20/D 1.403

bp

118-119 °C (lit.)

density

0.916 g/mL at 25 °C (lit.)

application(s)

environmental

format

neat

SMILES string

CC(O)COC

InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3

InChI key

ARXJGSRGQADJSQ-UHFFFAOYSA-N

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General description

1-Methoxy-2-propanol is one of the most common propylene-based glycol ethers that find potential use in several industrial and commercial applications, major use being as a component of paints, varnishes, inks, etc. It is often utilized as a less potent substitute for short-chained ethylene glycol ethers.

Application

1-Methoxy-2-propanol may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Flam. Liq. 3 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

93.2 °F - closed cup

Flash Point(C)

34 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J Laitinen et al.
Journal of chromatography. B, Biomedical sciences and applications, 694(1), 93-98 (1997-06-20)
At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol. The mean concentration was 2.52 (S.D. 2.01) mmol mol creatinine(-1) (median=1.76, n=23). The urinary excretion of 1,2-propanediol was linearly dependent
A biological monitoring study of 1-methoxy-2-propanol: analytical method development and a human volunteer study
Jones K, et al.
The Science of the Total Environment, 199(1-2), 23-30 (1997)
Gas-chromatographic determination of propylene-and diethylene glycol ethers in urine
Hubner B, et al.
Fresenius Journal of Analytical Chemistry, 342(9), 746-748 (1992)
N F Ferrala et al.
Journal of chromatography. B, Biomedical applications, 660(2), 291-296 (1994-10-14)
A method utilizing capillary GC and flame ionization detection was developed for the simultaneous determination of 1-methoxy-2-propanol (propylene glycol monomethyl ether; PGME) and its metabolite 1,2-propanediol (propylene glycol; PG) in rat and mouse plasma. The calibration graphs for rat and
S R Vink et al.
Regulatory toxicology and pharmacology : RTP, 58(1), 64-71 (2010-04-17)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in

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Learn about analyzing organic volatile impurities (OVIs) in pharmaceuticals using SH-GC, focusing on suitable solvents and ensuring compliance.

Learn about analyzing organic volatile impurities (OVIs) in pharmaceuticals using SH-GC, focusing on suitable solvents and ensuring compliance.

Learn about analyzing organic volatile impurities (OVIs) in pharmaceuticals using SH-GC, focusing on suitable solvents and ensuring compliance.

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