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Quality Level
product line
NovaSyn® TG
Novabiochem®
form
solid
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
2-8°C
General description
MeDbz NovaSyn TGR resin is a second generation Dbz resin that overcomes the problem of branched peptide formation of the original and provides a robust approach to the synthesis of peptide thioesters by Fmoc SPPS. This product is used exactly in the same manner as standard Dbz resins except that special conditions are not required for loading of the first amino acid. Peptide chain extension is performed on the 4-anilino group, followed by formation of an imidazolidinone (MeNbz) with p-nitrophenyl chloroformate, and cleavage from the resin with TFA. The peptide-MeNbz is used directly in chemical ligation reactions to generate in situ the desired peptide thioester.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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