Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

567732

Sigma-Aldrich

Sphingosine Kinase 1 Inhibitor, SKI-178

Synonym(s):

Sphingosine Kinase 1 Inhibitor, SKI-178, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H22N4O4
Molecular Weight:
394.42
UNSPSC Code:
12352200
NACRES:
NA.28

Assay

≥92% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Rui Sun et al.
Cell reports, 38(13), 110560-110560 (2022-03-31)
It is not clear how the complex interactions between diet and intestinal immune cells protect the gut from infection. Neutral ceramidase (NcDase) plays a critical role in digesting dietary sphingolipids. We find that NcDase is an essential factor that controls

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service