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1.09671

Supelco

1,4-Dioxane

for analysis EMSURE® ACS,ISO

Synonym(s):

1,4-Dioxane, Glycolethylether, 1,4-Diethylene dioxide, 1,4-Dioxacyclohexane

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About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
Molecular Weight:
88.11
MDL number:
UNSPSC Code:
12191504
EC Index Number:
204-661-8
NACRES:
NB.21

grade

ACS reagent

Quality Level

Agency

reag. ISO

vapor pressure

41 hPa ( 20 °C)

product line

EMSURE®

Assay

≥99.5% (GC)

form

liquid

autoignition temp.

300 °C

potency

5200 mg/kg LD50, oral (Rat)
7600 mg/kg LD50, skin (Rabbit)

expl. lim.

1.7-25.2 % (v/v)

impurities

≤0.0008 meq/g Acidity
≤0.005% Acetaldehyde
≤0.005% Peroxide (as H2O2)
≤0.01% Carbonyl compounds (as CO)
≤0.05% Formaldehyde
≤0.05% Water

evapn. residue

≤0.001%

color

APHA: ≤10

pH

6-8 (20 °C, 500 g/L in H2O)

bp

101.5 °C/1013 hPa

mp

12 °C

transition temp

flash point 11 °C

density

1.03 g/cm3 at 20 °C

cation traces

Al: ≤0.00005%
B: ≤0.000002%
Ba: ≤0.00001%
Ca: ≤0.00005%
Cd: ≤0.000005%
Co: ≤0.000002%
Cr: ≤0.000002%
Cu: ≤0.000002%
Fe: ≤0.00001%
Mg: ≤0.00001%
Mn: ≤0.000002%
Ni: ≤0.000002%
Pb: ≤0.00001%
Sn: ≤0.00001%
Zn: ≤0.00001%

storage temp.

2-30°C

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

General description

EMSURE grade solvents are suitable for a broad spectrum of classical lab applications, and are frequently used in regulated and highly demanding lab applications. EMSURE provides worldwide best and most extensive product specifications. We declare our EMSURE range to be in compliance with the ACS, with the reagent part of the European Pharmacopoeia (Reag. Ph Eur) and also with the ISO standards.

Application


  • Preferential Solvation Phenomena as Solute-Induced Structure-Making/Breaking Processes: Linking Thermodynamic Preferential Interaction Parameters to Fundamental Structure Making/Breaking Functions.: This study explores the solvation dynamics and interactions in solutions containing 1,4-dioxane, highlighting the solute′s influence on molecular arrangements and interactions (Chialvo AA, 2024).

  • Green Synthesis of Highly Fluorescent NCQDs: A Comprehensive Study on Synthesis, Characterization, Photophysical Properties, pH Sensing, Heavy Metal Detection, and Solvatochromic Behavior through Hydrothermal Method.: Discusses the development of nanocrystals using 1,4-dioxane as a solvent, focusing on their application in environmental monitoring and chemical sensing (Negi P et al., 2024).

  • Concentration Fluctuation/Microheterogeneity Duality Illustrated with Aqueous 1,4-Dioxane Mixtures.: This paper presents a theoretical analysis of the mixture behavior of water and 1,4-dioxane, providing insights into the molecular interactions and solution properties (Kolaříková A et al., 2024).

  • Synthesis, molecular docking studies and biological evaluation of N-(4-oxo-2-(trifluoromethyl)-4H-chromen-7-yl) benzamides as potential antioxidant, and anticancer agents.: Explores the synthesis of new compounds using 1,4-dioxane and their potential as therapeutic agents, highlighting the versatility of 1,4-dioxane in drug development (Jorepalli S et al., 2024).


Analysis Note

Purity (GC): ≥ 99.5 %
Identity (IR): conforms
Color: ≤ 10 Hazen
Acidity: ≤ 0.0008 meq/g
Density (d 20 °C/ 4 °C): 1.030 - 1.035
Melting point: ≥ 11.0 °C
Formaldehyde: ≤ 0.05 %
Acetaldehyde: ≤ 0.005 %
Peroxide (as H₂O₂): ≤ 0.005 %
Carbonyl compounds (as CO): ≤ 0.01 %
Evaporation residue: ≤ 0.001 %
Water: ≤ 0.05 %
Al (Aluminium): ≤ 0.00005 %
B (Boron): ≤ 0.000002 %
Ba (Barium): ≤ 0.00001 %
Ca (Calcium): ≤ 0.00005 %
Cd (Cadmium): ≤ 0.000005 %
Co (Cobalt): ≤ 0.000002 %
Cr (Chromium): ≤ 0.000002 %
Cu (Copper): ≤ 0.000002 %
Fe (Iron): ≤ 0.00001 %
Mg (Magnesium): ≤ 0.00001 %
Mn (Manganese): ≤ 0.000002 %
Ni (Nickel): ≤ 0.000002 %
Pb (Lead): ≤ 0.00001 %
Sn (Tin): ≤ 0.00001 %
Zn (Zinc): ≤ 0.00001 %
Stabilized with 25 ppm 2,6-Di-tert-butyl-4-methylphenol (BHT).
ACS, ISO-reagent

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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