1.00804

L(+)-Tartaric acid

for analysis EMSURE^® ACS,ISO,Reag. Ph Eur

• Synonym(s): L(+)-Tartaric acid, 2,3-Dihydroxybutanedioic acid
• Linear Formula: HOOCCH(OH)CH(OH)COOH
• CAS Number: 87-69-4
• Molecular Weight: 150.09
• MDL number: MFCD00064207
• UNSPSC Code: 12352106
• EC Index Number: 201-766-0
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 300
• Agency: reag. ISO; reag. Ph. Eur.; suitable for EPA 200.7; suitable for EPA 200.8
• vapor pressure: <5 Pa ( 20 °C)
• product line: EMSURE^®
• Assay: ≥99.5-101.0% dry basis (alkalimetric)
• form: solid
• autoignition temp.: 425 °C
• impurities: ≤10 ppm Phosphate (PO4); ≤100 ppm Sulfated ash; ≤20 ppm Total sulfur (as SO4); ≤350 ppm Oxalic acid; ≤5 ppm Chloride (Cl); ≤50 ppm Insoluble matter; ≤50 ppm Sulfate (SO4)
• loss: ≤ 0.2% loss on drying, 105°C
• pH: 1.6 (25 °C, 100 g/L in H₂O)
• mp: 168-170 °C
• transition temp: flash point 210 °C
• solubility: water: 1390 g/L at 20 °C
• density: 1.76 g/cm³ at 20 °C
• bulk density: 1000 kg/m³
• cation traces: Ca: ≤20 ppm; Cu: ≤5 ppm; Fe: ≤5 ppm; Pb: ≤5 ppm; heavy metals (as Pb): ≤5 ppm
• storage temp.: 2-30°C
• InChI: 1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)
• InChI key: FEWJPZIEWOKRBE-UHFFFAOYSA-N

Description

Application

• Binary Mixtures of Meloxicam and L-Tartaric Acid for Oral Bioavailability Modulation of Pharmaceutical Dosage Forms.: This study explores the use of L(+)-tartaric acid in binary mixtures to enhance the oral bioavailability of meloxicam, suggesting potential applications in developing more effective pharmaceutical formulations (Macasoi et al., 2024).


• Hyper-Raman spectroscopy of biomolecules.: This research employs Hyper-Raman spectroscopy, an analytical technique enhanced by L(+)-tartaric acid, to provide insights into the structural dynamics of biomolecules, showcasing its utility in complex biological systems (Marble et al., 2024).


• Novel multi-component crystals of berberine with improved pharmaceutical properties.: This study highlights the use of L(+)-tartaric acid in the development of novel multi-component crystals, potentially leading to pharmaceuticals with enhanced efficacy and stability (Zhang et al., 2023).


• Deep Eutectic Solvent (DES)-Mediated One-Pot Multicomponent Green Approach for Naphthalimide-Centered Acridine-1,8-dione Derivatives and Their Photophysical Properties.: Research demonstrates the synthesis of complex organic compounds using L(+)-tartaric acid as a component of a deep eutectic solvent, highlighting its role in green chemistry (Rather et al., 2022).

Linkage

Replaces: TX0010-1; TX0010

Analysis Note

Assay (alkalimetric): ≥ 99.5 %
Assay (alkalimetric, calculated on dried substance): 99.5 - 101.0 %
Identity: passes test
Appearance of solution: passes test
Insoluble matter: ≤ 50 ppm
Spec. rotation [α²0/D (20 %; water calculated on dried substance): 12.0 - 12.8 °
Chloride (Cl): ≤ 5 ppm
Phosphate (PO₄): ≤ 10 ppm
Sulfate (SO₄): ≤ 50 ppm
Heavy metals (as Pb): ≤ 5 ppm
Total sulfur (as SO₄): ≤ 20 ppm
Ca (Calcium): ≤ 20 ppm
Cu (Copper): ≤ 5 ppm
Fe (Iron): ≤ 5 ppm
Pb (Lead): ≤ 5 ppm
Oxalate (C₂O₄): passes test
Oxalic acid: ≤ 350 ppm
Sulfated ash: ≤ 100 ppm
Loss on Drying (105°C): ≤ 0.2 %
Corresponds to ACS,ISO,Reag. Ph Eur

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 302.0 °F - closed cup
• Flash Point(C): 150 °C - closed cup