900653
Poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone)
5k-10k-5k
Synonym(s):
PCL-PEG-PCL, PCL-PEG-PCL triblock copolymer
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Application
Biocompatible, amphiphilic triblock polymer composed of a hydrophilic, central PEG block and two terminal hydrophobic PCL blocks. These materials have been used in drug delivery applications as well as thermoplastic elastomers. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone) (PCL-PEG-PCL) nanoparticles: a valuable and efficient system for in vitro and in vivo delivery of curcumin.
Royal Society of Chemistry Advances, 6(17), 14403-14415 (2016)
International journal of pharmaceutics, 365(1-2), 89-99 (2008-09-17)
In this work, a series of biodegradable triblock poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) copolymers were successfully synthesized by ring-opening copolymerization, and were characterized by (1)H NMR, FT-IR, GPC, and DSC. Aqueous solutions of PECE copolymers underwent thermosensitive sol-gel-sol transition as
Synthesis and Characterization of PEG-PCL-PEG Triblock Copolymers as Carriers of Doxorubicin for the Treatment of Breast Cancer.
Journal of Applied Polymer Science, 117, 3694-3703 (2010)
Synthesis and microphase separation of biodegradable poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) multiblock copolymer films.
Macromolecular Research, 16(7), 609-613 (2008)
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