808601

(Bromodifluoromethyl)trimethylsilane

98%

• Empirical Formula (Hill Notation): C₄H₉BrF₂Si
• CAS Number: 115262-01-6
• Molecular Weight: 203.10
• MDL number: MFCD18641931
• UNSPSC Code: 12352101
• PubChem Substance ID: 329769113
• NACRES: NA.22
• form: liquid
• Assay: 98%

Properties

• description: Flash point: 46.4°C
• Assay: 98%
• form: liquid
• refractive index: n/D 1.407
• density: 1.306
• storage temp.: −20°C
• SMILES string: C[Si](C)(C(F)(F)Br)C
• InChI: 1S/C4H9BrF2Si/c1-8(2,3)4(5,6)7/h1-3H3
• InChI key: WDZVWBWAUSUTTO-UHFFFAOYSA-N

Description

General description

(Bromodifluoromethyl)trimethylsilane (TMSCF₂Br) is commonly used as a source to generate dilfluorocarbene. TMSCF₃ (Ruppert–Prakash reagent) and BBr₃ undergoes fast halogen–exchange reaction to form MSCF₂Br.

Application

(Bromodifluoromethyl)trimethylsilane may be used in the preparation of:

• gem-difluorocyclopropa(e)nes
• O-, S-, N-, and P-difluoromethylated compounds
• (chlorodifluoromethyl)trimethylsilane

As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.

Other Notes

Prof. Jinbo Hu′s Professor Product Page

Synthesis of gem-Difluorocyclopropa(e)nes and O-, S- N- and P-Difluoromethylated Compounds with TMSCF₂Br

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Warning
• Hazard Statements: H226,H315,H319,H335
• Precautionary Statements: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 115.5 °F
• Flash Point(C): 46.4 °C