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769800

Sigma-Aldrich

Resomer® RG 753 S, Poly(D,L-lactide-co-glycolide)

ester terminated, Lactide: Glycolide 75:25, lactide:glycolide 75:25

Synonym(s):

Poly(Glycolide Lactide)Copolymer, Poly(Lactide-Co-Glycolide), Resomer® RG 753 S, PLGA

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About This Item

Linear Formula:
HO[C2H4O2]n[C2H2O2]mCH3
CAS Number:
26780-50-7
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

form

amorphous

feed ratio

lactide:glycolide 75:25

viscosity

0.32-0.44 dL/g

transition temp

Tg 44-50 °C

storage temp.

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

Application

Resomer® RG 753 S, Poly(D,L-lactide-co-glycolide) is a biodegradable and biocompatible aliphatic polyester, which can be used in the development of nano and microparticles. It is a pharmaceutical polymer that can be potentially utilized in drug delivery and gene delivery. It forms a three-dimensional porous scaffold, which can be used in tissue engineering.

Legal Information

RESOMER is a registered trademark of Evonik Rohm GmbH

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nanoparticles made of fluorescence-labelled poly (L-lactide-co-glycolide): preparation, stability, and biocompatibility
Weiss B, et al.
Journal of Nanoscience and Nanotechnology, 6(9-10), 3048-3056 (2006)
Development and evaluation of novel biodegradable microspheres based on poly (d, l-lactide-co-glycolide) and poly (varepsilon-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: in vitro and in vivo studies
Mundargi RC, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 119(1), 59-68 (2007)
Nano/micro technologies for delivering macromolecular therapeutics using poly (D, L-lactide-co-glycolide) and its derivatives
Mundargi RC, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 125(3), 193-209 (2008)
In vitro degradation of three-dimensional porous poly (D, L-lactide-co-glycolide) scaffolds for tissue engineering
Wu L and Ding J
Biomaterials, 25(27), 5821-5830 (2004)

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