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755842

Sigma-Aldrich

6-Maleimidohexanoic acid

90% (GC)

Synonym(s):

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid, 6-Maleimide hexanoic acid, MCA, Maleimidocaproic acid, 6-Maleimidocaproic acid, N-Maleoyl-6-aminocaproic acid, N-(5-Carboxypentyl)maleimide

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About This Item

Empirical Formula (Hill Notation):
C10H13NO4
CAS Number:
55750-53-3
Molecular Weight:
211.21
Beilstein:
1532405
MDL number:
MFCD00043140
UNSPSC Code:
12162002
PubChem Substance ID:
329766144
NACRES:
NA.23

Assay

90% (GC)

form

powder

mp

87-92 °C

storage temp.

2-8°C

SMILES string

OC(=O)CCCCCN1C(=O)C=CC1=O

InChI

1S/C10H13NO4/c12-8-5-6-9(13)11(8)7-3-1-2-4-10(14)15/h5-6H,1-4,7H2,(H,14,15)

InChI key

WOJKKJKETHYEAC-UHFFFAOYSA-N

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Application

Probe for thiol groups (SH-groups) in membrane proteins.
Intermediate for ester and amide linked maleimide monomers

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H335

Hazard Classifications

Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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D B R K Gupta Udatha et al.
Journal of structural biology, 190(3), 314-327 (2015-04-25)
The catalytic residues in carbohydrate esterase enzyme families constitute a highly conserved triad: serine, histidine and aspartic acid. This catalytic triad is generally located in a very sharp turn of the protein backbone structure, called the nucleophilic elbow and identified
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Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) encodes a tumor suppressor gene implicated in the growth of various tumor types including breast cancer. We previously demonstrated that recombinant adenovirus-mediated mda-7/IL-24 expression in the mammary glands of carcinogen-treated (methylnitrosourea, MNU) rats suppressed mammary
Joanna M Wardlaw et al.
International journal of stroke : official journal of the International Stroke Society, 10(6), 956-968 (2013-01-23)
Intravenous thrombolysis with recombinant tissue Plasminogen Activator improves outcomes in patients treated early after stroke but at the risk of causing intracranial hemorrhage. Restricting recombinant tissue Plasminogen Activator use to patients with evidence of still salvageable tissue, or with definite
Mohammed Abdelsaid et al.
Life sciences, 118(2), 268-273 (2014-01-23)
We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1
Nathalie E Blachère et al.
European journal of immunology, 44(11), 3240-3251 (2014-08-12)
Paraneoplastic neurologic diseases (PND) involving immune responses directed toward intracellular antigens are poorly understood. Here, we examine immunity to the PND antigen Nova2, which is expressed exclusively in central nervous system (CNS) neurons. We hypothesized that ectopic expression of neuronal
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