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739626

Sigma-Aldrich

25-Hydroxyvitamin D3 (6,19,19-d3) solution

5 μg/mL in ethanol, 97 atom % D, 98% (CP)

Synonym(s):

25-Hydroxycholecalciferol (6,19,19-d3) solution, Deuterated 25-hydroxyvitamin D3

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About This Item

Empirical Formula (Hill Notation):
C27D3H41O2
CAS Number:
140710-94-7
Molecular Weight:
403.66
EC Number:
200-578-6
MDL number:
MFCD11656128
UNSPSC Code:
12352106
PubChem Substance ID:
329765366
NACRES:
NA.24

isotopic purity

97 atom % D

Assay

98% (CP)

form

liquid

concentration

5 μg/mL in ethanol

technique(s)

mass spectrometry (MS): suitable

color

colorless

application(s)

detection

mass shift

M+3

storage temp.

−20°C

SMILES string

[2H]/C([2H])=C1CC[C@H](O)CC\1=C([2H])\C=C2/CCC[C@]3(C)[C@H](CC[C@@H]23)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1/i1D2,12D

InChI key

JWUBBDSIWDLEOM-CMMPNOGOSA-N

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General description

25-Hydroxyvitamin D3 (calcifediol) is a prohormone produced via hydroxylation of vitamin D3 (cholecalciferol) in the liver. It is a precursor for the synthesis of calcitriol {1,25-dihydroxyvitamin D3 or [1,25(OH)2D3]}. It is also used as a biomarker to determine the status of vitamin D in the body.
25-Hydroxyvitamin D3 (6,19,19-d3) is a deuterated 25-hydroxyvitamin D3 wherein C-6 and C-19 protons are replaced by deuterium.

Application

25-Hydroxyvitamin D3 (6,19,19-d3) can be used as an analytical standard for the quantitative analysis of hydroxyvitamin D3 concentration in human serum via LC-MS.

Packaging

1 mL in ampule

related product

Product No.
Description
Pricing

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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25-Hydroxyvitamin D3, the prohormone of 1, 25-dihydroxyvitamin D3, inhibits the proliferation of primary prostatic epithelial cells
Barreto, AM et al.
Cancer Epidemiology, Biomarkers & Prevention, 9(3), 265-270 (2000)
Quantification of circulating 25-hydroxyvitamin D by liquid chromatography-tandem mass spectrometry
Vogeser M
The Journal of Steroid Biochemistry and Molecular Biology, 121(3-5), 565-573 (2010)
Jiri Adamec et al.
Journal of separation science, 34(1), 11-20 (2010-12-21)
Simultaneous and accurate measurement of vitamin D and 25-hydroxyvitamin D in biological samples is a barrier limiting our ability to define "optimal" vitamin D status. Thus, our goal was to optimize conditions and evaluate an LC-MS method for simultaneous detection

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