530301

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride

97%

• Synonym(s): 2-(Chloromethyl)-3,4-dimethoxypyridinium hydrochloride
• Empirical Formula (Hill Notation): C₈H₁₁Cl₂NO₂
• CAS Number: 72830-09-2
• Molecular Weight: 224.08
• Beilstein: 5360726
• EC Number: 416-440-5
• MDL number: MFCD02181083
• UNSPSC Code: 12352100
• PubChem Substance ID: 24877740
• NACRES: NA.22

Properties

• Assay: 97%
• mp: 155 °C (dec.) (lit.)
• functional group: chloro
• SMILES string: Cl[H].COc1ccnc(CCl)c1OC
• InChI: 1S/C8H10ClNO2.ClH/c1-11-7-3-4-10-6(5-9)8(7)12-2;/h3-4H,5H2,1-2H3;1H
• InChI key: YYRIKJFWBIEEDH-UHFFFAOYSA-N

Description

General description

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (CDP) can be synthesized using maltol as a starting material. CDP and DMS (dimethyl sulfate) are used in the preparation of pantoprazole sodium (PPS), an antiulcerative drug. The quantification of CDP and DMS in PPS can be done simultaneously by gas chromatography–mass spectrometry (GC-MS) method.

Application

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride may be used as a precursor for the preparation [(2-pyridyl)-2-ethyl]-[3,4-dimethoxy-(2-pyridylmethyl)]-N-methylamine.

Safety Information

• Pictograms: GHS08,GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302 + H312,H315,H317,H318,H373,H411
• Precautionary Statements: P273 - P280 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves