47622

Fmoc-Thr(tBu)-OH

≥98.0% (HPLC), for peptide synthesis

• Synonym(s): Fmoc-O-tert-butyl-L-threonine
• Empirical Formula (Hill Notation): C₂₃H₂₇NO₅
• CAS Number: 71989-35-0
• Molecular Weight: 397.46
• Beilstein: 4581133
• EC Number: 276-261-1
• MDL number: MFCD00077075
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 57651042
• NACRES: NA.26

Properties

• Product Name: Fmoc-Thr(tBu)-OH, ≥98.0% (HPLC)
• Quality Level: 100
• Assay: ≥98.0% (HPLC)
• optical activity: [α]20/D +16±1°, c = 1% in ethyl acetate
• reaction suitability: reaction type: C-H Activation; reaction type: Fmoc solid-phase peptide synthesis; reagent type: ligand; reaction type: Peptide Synthesis
• application(s): peptide synthesis
• functional group: Fmoc; amine; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
• InChI: 1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/t14-,20+/m1/s1
• InChI key: LZOLWEQBVPVDPR-VLIAUNLRSA-N

Description

General description

Fmoc-Thr(tBu)-OH also known as Fmoc-O-tert-butyl-L-threonine, is commonly used as amino acid building block in peptide synthesis.

Application

Fmoc-Thr(tBu)-OH can be used to synthesize chlorofusin analogues via solid phase peptide synthesis. Additionally, it can serve as a protecting group for both the amine and the hydroxyl functions in solid-phase synthesis of complex depsipeptides.[1] [2]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves