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130532

Sigma-Aldrich

5,7-Dichloro-8-hydroxy-2-methylquinoline

98%

Synonym(s):

5,7-Dichloro-2-methyl-8-quinolinol, 5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-8-quinaldinol, BCM

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About This Item

Empirical Formula (Hill Notation):
C10H7Cl2NO
CAS Number:
72-80-0
Molecular Weight:
228.07
Beilstein:
156683
EC Number:
200-789-3
MDL number:
MFCD00023984
UNSPSC Code:
12352100
PubChem Substance ID:
24847966
NACRES:
NA.22

Assay

98%

mp

108-112 °C (dec.) (lit.)

SMILES string

Cc1ccc2c(Cl)cc(Cl)c(O)c2n1

InChI

1S/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3

InChI key

GPTXWRGISTZRIO-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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I Corrihons et al.
Pathologie-biologie, 39(2), 136-139 (1991-02-01)
The activity of chlorquinaldol, a derivative of hydroxy-8-quinolein used for local antisepsy, was studied against Neisseria gonorrhoeae and Chlamydia trachomatis. The weak solubility of the product and the special growth conditions of the organisms made an adaptation of the AFNOR
A double-blind comparative study to compare the efficacy of Locoid C with Tri-Adcortyl in children with infected eczema.
F O Meenan
The British journal of clinical practice, 42(5), 200-202 (1988-05-01)
Tzu-Shean Feng et al.
Biochemical pharmacology, 82(3), 236-247 (2011-05-21)
4-Aminoquinolines were hybridized with artemisinin and 1,4-naphthoquinone derivatives via the Ugi-four-component condensation reaction, and their biological activities investigated. The artemisinin-containing compounds 6a-c and its salt 6c-citrate were the most active target compounds in the antiplasmodial assays. However, despite the potent
Contact cross-sensitization among quinolines.
A Rodríguez et al.
Allergy, 56(8), 795-795 (2001-08-08)
A Dimitrova et al.
Akusherstvo i ginekologiia, 46(1), 46-47 (2007-05-02)
The data of 30 nonpregnant women in reproductive age BV treated with Gynalgin were presented. On clinical and microbiological indicator Gynalgin showed a good effect on BV-associated microorganisms (80%). Only one of the cases of BV was not affected (4%).
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