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130001

Sigma-Aldrich

1-Methylpiperazine

99%

Synonym(s):

N-Methylpiperazine

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About This Item

Empirical Formula (Hill Notation):
C5H12N2
CAS Number:
109-01-3
Molecular Weight:
100.16
Beilstein:
102724
EC Number:
203-639-5
MDL number:
MFCD00005966
UNSPSC Code:
12352100
PubChem Substance ID:
24847936
NACRES:
NA.22

vapor density

3.5 (vs air)

Quality Level

200

Assay

99%

form

liquid

refractive index

n20/D 1.466 (lit.)

bp

138 °C (lit.)

density

0.903 g/mL at 25 °C (lit.)

SMILES string

CN1CCNCC1

InChI

1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3

InChI key

PVOAHINGSUIXLS-UHFFFAOYSA-N

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General description

1-Methylpiperazine is a heterocyclic diamine used as a versatile building block and intermediate in organic synthesis.

Application

1-Methylpiperazine was used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

88.7 °F - closed cup

Flash Point(C)

31.5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Juxiang Ruan et al.
Journal of chromatography. A, 1297, 77-84 (2013-06-01)
This paper reports the preparation of a novel, silica-based, strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative. To prepare the difunctional strong anion-exchange stationary phase, activated silica beads were first bonded with 3-chloropropyltriethoxysilane and then reacted with 1-methylpiperazine followed by
Hongyuan Yan et al.
The Analyst, 137(12), 2884-2890 (2012-05-04)
A highly selective molecularly imprinted solid-phase extraction (MISPE) combined with liquid chromatography-ultraviolet detection was developed for the simultaneous isolation and determination of four plant hormones including indole-3-acetic acid (IAA), indole-3-propionic acid (IPA), indole-3-butyric acid (IBA) and 1-naphthaleneacetic acid (NAA) in
H Welinder et al.
International archives of allergy and applied immunology, 79(3), 259-262 (1986-01-01)
The presence of specific IgE antibodies against conjugates between human serum albumin and piperazine, a compound previously known to cause occupational asthma, and N-methyl-piperazine, respectively, was demonstrated by RAST, RAST inhibition and skin prick tests in 2 asthmatic subjects occupationally
E Gavathiotis et al.
Nucleic acids research, 28(3), 728-735 (2000-01-19)
The solution structure of the dodecamer duplex d(CTTTTGCAAAAG)(2)and its 2:1 complex with the bis -benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restrained molecular dynamics (rMD) simulations. Drug molecules are bound in each of the two A-tracts with the
Andrius Žilionis
European journal of mass spectrometry (Chichester, England), 26(1), 25-35 (2019-08-21)
Liquid chromatography-tandem mass spectrometry is one of the most sensitive tools for determination of trace amounts of analytes in metabolomics and proteomics. The highest sensitivity is achieved in selected reaction monitoring detection, which involves fragmentation of the molecular ion between
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