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102687

Sigma-Aldrich

Ethylmalonic acid

97%

Synonym(s):

α-Carboxybutyric acid, 2-Ethylpropanedioic acid

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About This Item

Linear Formula:
C2H5CH(COOH)2
CAS Number:
601-75-2
Molecular Weight:
132.11
Beilstein:
774334
EC Number:
210-007-2
MDL number:
MFCD00002668
UNSPSC Code:
12162002
PubChem Substance ID:
24846585
NACRES:
NA.23

Assay

97%

form

solid

mp

112-114 °C (lit.)

SMILES string

CCC(C(O)=O)C(O)=O

InChI

1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9)

InChI key

UKFXDFUAPNAMPJ-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Patrícia Fernanda Schuck et al.
Synapse (New York, N.Y.), 67(3), 111-117 (2012-11-20)
Ethylmalonic acid (EMA) accumulates in tissues of patients affected by short-chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy, illnesses characterized by variable neurological symptoms. In this work, we investigated the in vitro and in vivo EMA effects on Na(+), K(+)-ATPase (NAK)
B Merinero et al.
Journal of inherited metabolic disease, 29(5), 685-685 (2006-08-15)
High concentrations of butyryl/isobutyrylcarnitine (C(4)-carnitine) in plasma with increase of ethylmalonic acid (EMA) in urine point to different genetic entities, and further investigations are required to differentiate the possible underlying defect. Here we report three unrelated cases, two neurologically affected
Lessons to learn from rare inborn errors of metabolism.
B Plecko
Neuropediatrics, 38(2), 59-60 (2007-08-23)
Patrícia Fernanda Schuck et al.
Behavioural brain research, 197(2), 364-370 (2008-10-28)
High concentrations of ethylmalonic acid (EMA) are found in tissues and biological fluids of patients affected by ethylmalonic encephalopathy (EE), as well as by deficiency of short-chain acyl-CoA dehydrogenase (SCAD) activity and other illnesses characterized by developmental delay and other
Imad Dweikat et al.
Metabolic brain disease, 27(4), 613-616 (2012-05-16)
Ethylmalonic encephalopathy (EE) is a rare autosomal recessive disorder caused by mutations in the ETHE1 gene and characterized by chronic diarrhea, encephalopathy, relapsing petechiae and acrocyanosis. Nephrotic syndrome has been described in an infant with EE but the renal histology
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