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Furosemide

Name: Furosemide
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₁ClN₂O₅S

CAS Number:

54-31-9

Molecular Weight:

330.74

NACRES:

NA.24

PubChem Substance ID:

329749916

UNSPSC Code:

41116107

MDL number:

MFCD00010549

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Properties

grade

pharmaceutical primary standard

API family

furosemide

manufacturer/tradename

USP

mp

220 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Furosemide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Furosemide Injection
Furosemide Oral Solution
Furosemide Tablets

Biochem/physiol Actions

Inhibits ion co-transport in the kidney.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	BP547	Y0001493	F0700000
USP 1287008 Furosemide	BP547 Furosemide	Y0001493 Furosemide for peak identification	F0700000 Furosemide
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
manufacturer/tradename USP	manufacturer/tradename BP	manufacturer/tradename EDQM	manufacturer/tradename EDQM
format neat	format neat	format neat	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
API family furosemide	API family furosemide	API family furosemide	API family furosemide
mp 220 °C (dec.) (lit.)	mp 220 °C (dec.) (lit.)	mp 220 °C (dec.) (lit.)	mp 220 °C (dec.) (lit.)

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360FD

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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Loop diuretic dose adjustments after a hospitalization for heart failure: insights from ASCEND-HF.

Adam D DeVore et al.

European journal of heart failure, 17(3), 340-346 (2015-01-27)

Loop diuretics are a cornerstone of heart failure (HF) treatment, but data regarding diuretic dose adjustments after a HF hospitalization and the association with subsequent outcomes are limited. This study was therefore conducted to determine these factors. We analysed data

Narrative review: furosemide for hypercalcemia: an unproven yet common practice.

Susan B LeGrand et al.

Annals of internal medicine, 149(4), 259-263 (2008-08-20)

Although primary hyperparathyroidism is the most common cause of hypercalcemia, cancer is the most common cause requiring inpatient intervention. An estimated 10% to 20% of all patients with cancer have hypercalcemia at some point in their disease trajectory, particularly in

Benefits and risks of furosemide in acute kidney injury.

K M Ho et al.

Anaesthesia, 65(3), 283-293 (2010-01-21)

Furosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain. This review summarises the pharmacology of furosemide, its potential uses and side effects, and the evidence of its efficacy.

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Global Trade Item Number

SKU	GTIN
1287008-200MG	04061838725875

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