V4253

[β-Mercapto-β,β-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₅₃H₇₅N₁₃O₁₁S₂
• CAS Number: 77453-01-1
• Molecular Weight: 1134.37
• NACRES: NA.32
• PubChem Substance ID: 329829049
• UNSPSC Code: 51111800
• MDL number: MFCD00076752
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥97% (HPLC)

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• solubility: water: 1 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC2=O)C(C)C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1
• InChI: 1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,44-/m0/s1
• InChI key: SDFJYGJKEXYVCG-ZZTMPEIHSA-N
• Gene Information: human ... AVPR1A(552), AVPR2(554), OXT(5020), OXTR(5021) ; mouse ... AVPR1A(54140), AVPR2(12000) ; rat ... AVPR1A(25107), AVPR2(25108), OXT(18429), OXTR(18430)

Description

Application

[Beta-Mercapto-beta, beta-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin is a potent V1a and V2 vasopressin receptor anatgonist, used for examining the impact of vasopressin V1receptor blockade in rats.[1]The product was also be used for visualizing cell surface V1a receptors in rat hepatocytes by using high-affinity fluorescent linear antagonist, Rhm8 -PVA.[2]

Biochem/physiol Actions

Vasopressin also known as antidiuretic hormone (ADH) or argipressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.[3]ADH can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.[4]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H332
• pcodes: P261 - P271 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves