SML2997

GHP-88309

≥98% (HPLC), paramyxovirus polymerase inhibitor, powder

• Synonym(s): 2-Fluoro-6-(5-isoquinolinyl)benzamide; 2-Fluoro-6-(5-isoquinolyl)benzamide, GHP 88309, GHP88309
• Empirical Formula (Hill Notation): C₁₆H₁₁FN₂O
• CAS Number: 1269267-87-9
• Molecular Weight: 266.27
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: GHP-88309, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=C(C(N)=O)C(C2=C(C=CN=C3)C3=CC=C2)=CC=C1
• InChI key: OLNVLPGIADWVKU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GHP-88309 is an orally available non-nucleoside paramyxovirus polymerase inhibitor with broad-spectrum anti-paramyxoviral activity (EC50 in μM= 0.4/HPIV3-JS, 0.8/HPIV3-5F6, 2/SeV-F1R-eGF, 0.6/MeV/Alaska.USA 16.00, 0.4/CDV-5804p) and little cytoxicity (CC50 >20μM). GHP-88309 potently inhibits the replication of HPIV1 isolate 5F6 and HPIV3 isolates 10L3 & 9R4 in 3D-ALI-HBTEC human airway organoids (EC50 = 280,90, 105 nM, respectively) in 3D-ALI-HBTECs. HPIV3 and provides complete protection against lethal Sendai virus infection in mice (150 mg/kg bid. po. starting at time of infection or 48 hrs after), a murine surrogate model of human HPIV3 disease.

Orally available non-nucleoside paramyxovirus polymerase inhibitor with broad-spectrum anti-paramyxoviral activity in vitro and in vivo.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable