SML1858

AZD2461

≥98% (HPLC)

• Synonym(s): 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one, 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone, AZD 2461, AZD-2461
• Empirical Formula (Hill Notation): C₂₂H₂₂FN₃O₃
• CAS Number: 1174043-16-3
• Molecular Weight: 395.43
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD24386811
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=CC=CC=C41
• InChI: 1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)
• InChI key: HYNBNUYQTQIHJK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.

Orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable