Key Documents

View All Documentation

Fialuridine

Name: Fialuridine
Brand: SIGMA

≥98% (HPLC), powder, nucleoside analog

Synonym(s):

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione, FIAU

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₉H₁₀FIN₂O₅

CAS Number:

69123-98-4

Molecular Weight:

372.09

UNSPSC Code:

12352200

PubChem Substance ID:

329825571

NACRES:

NA.77

MDL number:

MFCD00866922

Assay:

≥98% (HPLC)

Form:

powder

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Fialuridine, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(C(I)=C2)=O)=O

InChI

1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1

InChI key

IPVFGAYTKQKGBM-BYPJNBLXSA-N

Description

General description

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) is an antiviral agent. It is a thymidine-based nucleoside analogue.

Application

Fialuridine has been used in the selection of clones.

Biochem/physiol Actions

Fialuridine is a nucleoside analog antiviral agent.

Fialuridine is a nucleoside analog antiviral agent. The compound displays significant mitochondrial toxicity.

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) and its metabolites blocks DNA polymerase at sites of multiple adjacent analog incorporation, reduces the presence of mtDNA (mitochondrial DNA) and results in mitochondrial structural defects in cultured hepatoblasts. It is considered as an efficient drug against hepatitis B virus (HBV) infection.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	F6627	D1413	U1128
Sigma-Aldrich SML0632 Fialuridine	Sigma-Aldrich F6627 5-Fluorouracil	Sigma-Aldrich D1413 2′,3′-Didehydro-3′-deoxythymidine	Sigma-Aldrich U1128 Uracil
description ≥98% (HPLC)	description ≥99% (HPLC), powder	description ≥98% (TLC)	description BioReagent, suitable for cell culture
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥99% (HPLC)	assay ≥98% (TLC)	assay ≥99% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. room temp	storage temp. −20°C	storage temp. room temp
solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO/DMF: soluble, methanol: soluble, 1 M NH4OH: soluble	solubility -	solubility 1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
color white to beige	color white	color -	color -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.