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S7010

Sigma-Aldrich

Span® 60

Synonym(s):

Sorbitan stearate, Sorbitane monostearate

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About This Item

CAS Number:
1338-41-6
EC Number:
215-664-9
MDL number:
MFCD00005366
UNSPSC Code:
12161900
PubChem Substance ID:
24899728
NACRES:
NA.25

description

non-ionic

mol wt

430.63 g/mol

concentration

45-55% (GC)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24+/m0/s1

InChI key

HVUMOYIDDBPOLL-XGKPLOKHSA-N

Related Categories

General description

Span® 60 is a sorbitan monoester than is used as a non-ionic detergent.

Application

Span® 60 has been used in a study to assess encapsulation of doxorubicin in niosomes as a route to tumor targeting. It has also been used in a study to investigate the use of nonionic surfactants as contrast agents for use in diagnostic ultrasounds.

Other Notes

Fatty acid composition: Stearic acid (C18:0) approx. 50%; balance primarily palmitic acid (C16:0).

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preparation and properties of vesicles (niosomes) of sorbitan monoesters ([TM="Span"] 20, 40, 60 and 80) and a sorbitan triester ([TM="Span"] 85).
Yoshioka, T., et al.
International Journal of Pharmaceutics, 105, 1-1 (1994)
I F Uchegbu et al.
Pharmaceutical research, 12(7), 1019-1024 (1995-07-01)
Encapsulation of doxorubicin in niosomes was sought as a route to tumour targeting and improved tumoricidal through the alteration of doxorubicin pharmacokinetics and metabolism. Doxorubicin niosomes (10 mg kg-1 doxorubicin) prepared from sorbitan monostearate (Span 60), cholesterol and choleth-24 (a
Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of [TM="Span"] 60 and Tween 80 mixtures using a Langmuir trough
Singhal, S., et al.
Langmuir, 9, 2426-2426 (1993)
Isabel F Almeida et al.
International journal of pharmaceutics, 327(1-2), 73-77 (2006-09-26)
Oleogels are semisolid systems obtained with an organogelator and a hydrophobic liquid that have been investigated over the past few years and that could play an important role as dermatological bases. Recently, we have developed an oleogel of sorbitan monostearate
Ismail A Attia et al.
AAPS PharmSciTech, 8(4), E106-E106 (2008-01-10)
The purpose of this research was to prepare acyclovir niosomes in a trial to improve its poor and variable oral bioavailability. The nonionic surfactant vesicles were prepared by the conventional thin film hydration method. The lipid mixture consisted of cholesterol
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