P8765

Ammonium pyrrolidinedithiocarbamate

~99%

• Synonym(s): 1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC
• Linear Formula: C₅H₉NS₂ · NH₃
• CAS Number: 5108-96-3
• Molecular Weight: 164.29
• Beilstein: 3730472
• EC Number: 225-834-4
• MDL number: MFCD00012720
• UNSPSC Code: 12352107
• PubChem Substance ID: 24278658
• NACRES: NA.77

Properties

• biological source: microbial
• Assay: ~99%
• form: (powderor powder with lumps)
• mp: 153-155 °C (lit.)
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: N.SC(=S)N1CCCC1
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• InChI key: MDDIUTVUBYEEEM-UHFFFAOYSA-N
• Gene Information: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) , RELA(5970)

Description

General description

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Application

Ammonium pyrrolidinedithiocarbamate has been used:

• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves