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Pargyline hydrochloride

Name: Pargyline hydrochloride
Brand: SIGMA

synthetic, 98% (TLC), MAO-B inhibitor, powder or crystals

Synonym(s):

N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride

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About This Item

Linear Formula:

C₆H₅CH₂N(CH₃)CH₂C≡CH·HCl

CAS Number:

306-07-0

Molecular Weight:

195.69

NACRES:

NA.77

PubChem Substance ID:

24278153

UNSPSC Code:

12352200

EC Number:

206-175-1

MDL number:

MFCD00012492

Beilstein/REAXYS Number:

3699487

Assay:

98% (TLC)

Form:

powder or crystals

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Properties

Product Name

Pargyline hydrochloride,

biological source

synthetic

Quality Segment

200

assay

98% (TLC)

form

powder or crystals

mp

160-163 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].CN(CC#C)Cc1ccccc1

InChI

1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

InChI key

BCXCABRDBBWWGY-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

Description

Application

Pargyline hydrochloride has been used:

as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.

Selective MAO-B inhibitor.

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This Item	SML0667	B019	M003
Sigma-Aldrich P8013 Pargyline hydrochloride	Sigma-Aldrich SML0667 PF-429242 dihydrochloride	Sigma-Aldrich B019 Phenoxybenzamine hydrochloride	Sigma-Aldrich M003 R-(−)-Deprenyl hydrochloride
form powder or crystals	form powder	form powder	form powder
assay 98% (TLC)	assay ≥98% (HPLC)	assay ≥97%	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -
solubility water: 50 mg/mL, clear, colorless to faintly yellow	solubility H₂O: 15 mg/mL, clear	solubility H₂O: slightly soluble, alcohol: soluble, propylene glycol: soluble	solubility H₂O: >10 mg/mL
Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information -	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... MAOB(4129)

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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