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P3252

Sigma-Aldrich

6-Phenyl-2-thiouracil

≥95%

Synonym(s):

2-Mercapto-6-phenyl pyrimidine-4-ol, 6-Phenylthiouracil, Fenucil

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About This Item

Empirical Formula (Hill Notation):
C10H8N2OS
CAS Number:
36822-11-4
Molecular Weight:
204.25
EC Number:
253-227-4
MDL number:
MFCD00059166
UNSPSC Code:
41106305
PubChem Substance ID:
24897877
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

100

Assay

≥95%

form

powder

solubility

DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow

SMILES string

Oc1cc(nc(S)n1)-c2ccccc2

InChI

1S/C10H8N2OS/c13-9-6-8(11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)

InChI key

XEKNACRTWJHOCE-UHFFFAOYSA-N

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Application

6-Phenyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Abuín et al.
Analytica chimica acta, 617(1-2), 184-191 (2008-05-20)
A method based on ultra-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry for the determination of six thyreostatic drugs in thyroid tissue has been optimised and validated in accordance with the Decision 2002/657/EC. Samples are extracted with methanol and the extracts cleaned-up
Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives.
M Baba et al.
Antiviral research, 17(4), 245-264 (1992-04-01)
Tomás Pérez-Ruiz et al.
Electrophoresis, 26(12), 2384-2390 (2005-05-17)
This paper reports the development of a method based on capillary electrophoresis with laser-induced fluorescence detection for the simultaneous determination of thiouracil (TU) and phenylthiouracil (PhTU) with high sensitivity (nanomolar range, i.e., attomoles detected). After derivatization with 5-iodoacetamidofluorescein, the analytes
Dexian Kong et al.
Electrophoresis, 30(19), 3489-3495 (2009-09-04)
A simple, rapid, reproducible and sensitive method based on CE with electrochemical detector was developed for the simultaneous determination of five thyreostatics including 2-thiouracil (TU), 6-methyl-2-thiouracil (MTU), 6-propyl-2-thiouracil (PTU), 6-phenyl-2-thiouracil (PhTU) and methimazole (TAP) in animal feeds. A home-made wall-jet
Yuan Liu et al.
Rapid communications in mass spectrometry : RCM, 21(9), 1504-1510 (2007-03-31)
A novel approach for determination of 2-mercaptobenzimidazole (MBI) and other thyreostatic residues in animal tissues by gas chromatography/mass spectrometry (GC/MS) in selected ion monitoring mode was developed. The analytes in animal tissues (including hypothyroid, pork muscle and beef samples) were
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