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Naltriben methanesulfonate hydrate

Name: Naltriben methanesulfonate hydrate
Brand: SIGMA

≥98% (HPLC), δ2 opioid receptor antagonist, solid

Synonym(s):

NTB hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₅NO₄ · CH₄O₃S · xH₂O

CAS Number:

1309441-44-8

Molecular Weight:

511.59 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24278045

NACRES:

NA.77

MDL number:

MFCD11046015

Assay:

≥98% (HPLC)

Form:

solid

Pricing and availability is not currently available.

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Properties

Product Name

Naltriben methanesulfonate hydrate, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

off-white

solubility

DMSO: 14 mg/mL at ~60 °C

storage temp.

−20°C

SMILES string

O.CS(O)(=O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6oc7ccccc7c6C[C@@]35O)CC8CC8

InChI

1S/C26H25NO4.CH4O3S.H2O/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14;1-5(2,3)4;/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2;1H3,(H,2,3,4);1H2/t20-,24+,25+,26-;;/m1../s1

InChI key

VAGWKZSGWSRENH-HIAJFTJMSA-N

Description

Application

Naltriben methanesulfonate hydrate has been used in the assessment of parasite growth and evaluation of growth inhibition. It has also been used to understand the action of deltorphin-II in exhibiting its antimalarial effect.

Biochem/physiol Actions

Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkephalin > deltorphin II = DPDPE = etorphine > levallorphan = diprenorphine = nalorphine = naltrindole.

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This Item	B2417	T200	R5655
Sigma-Aldrich N156 Naltriben methanesulfonate hydrate	Sigma-Aldrich B2417 Benzamil hydrochloride hydrate	Sigma-Aldrich T200 (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate	Sigma-Aldrich R5655 Rebamipide hydrate
description ≥98% (HPLC), solid	description ≥98% (HPLC)	description ≥97% (HPLC), solid	description ≥98% (HPLC), powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form powder
drug control regulated under CDSA - not available from Sigma-Aldrich Canada	drug control -	drug control -	drug control -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. -	storage temp. -
solubility DMSO: 14 mg/mL at ~60 °C	solubility DMSO: >20 mg/mL, methanol: 10 mg/mL	solubility DMSO: insoluble, H₂O: 16 mg/mL	solubility DMSO: >5 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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