Yes, α-Lactalbumin is a glycoprotein. It is a protein that is found in the milk of mammals and plays a crucial role in the synthesis of lactose in the mammary glands. Glycoproteins like α-Lactalbumin have carbohydrate groups attached to the polypeptide chain, which can influence their function and stability. In the case of α-Lactalbumin, these glycosylation modifications are important for its biological activity and interactions.
L5385
α-Lactalbumin from bovine milk
Type I, ≥85% (PAGE), lyophilized powder
Synonym(s):
Bos d 4, Lactose synthase B protein, alpha-lactalbumin
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About This Item
Biological source:
bovine milk
Assay:
≥85% (PAGE)
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable, electrophoresis: suitable
Impurities:
calcium, tested
Concentration:
≥85 % protein
Pricing and availability is not currently available.
biological source
bovine milk
Quality Segment
type
Type I
assay
≥85% (PAGE)
form
lyophilized powder
concentration
≥85 % protein
technique(s)
cell culture | mammalian: suitable, electrophoresis: suitable
impurities
calcium, tested
solubility
H2O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... LALBA(281894)
General description
α-Lactalbumin is a small, globular, whey protein that has been found in all milk studied to date. It is a metalloprotein of approximately 14 kDa produced in the mammary glands.[1]
Application
α-Lactalbumin from bovine milk has been used as a supplement of basal medium for various cell cultures. It has also been used as a marker for sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).
Biochem/physiol Actions
α-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form.[2] α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex. [3][4] The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Α° resolution, demonstrating four α-helices and a triple stranded antiparallel β-sheet.[1]
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.
Analysis Note
Calcium saturated. May have traces of ammonium sulfate and sodium phosphate
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This Item | |||
|---|---|---|---|
| biological source bovine milk | biological source bovine milk | biological source bovine milk | biological source bovine milk |
| technique(s) cell culture | mammalian: suitable, electrophoresis: suitable | technique(s) indirect ELISA: suitable | technique(s) electrophoresis: suitable | technique(s) microbiological culture: suitable |
| assay ≥85% (PAGE) | assay ≥85% (PAGE) | assay - | assay - |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form powder | form lyophilized powder |
| impurities calcium, tested | impurities cation traces, tested | impurities - | impurities - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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α-Lactalbumin is a glycoprotéine? Bonjour votre α-Lactalbumin est une glycoprotéine ou pas svp?
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